Development of lab-on-chip applications and implantable biosensors is the main focus of this area. Lab-on-chip applications are mainly for bio-detection and separation purposes. Related to this area, miniaturized bioreactors for cell culture are being developed. Implantable biosensors are mainly focused on strain and deformation sensors as well as magnetoelectric actuators.


 Smart Prothesis            Bioreactores for Cell Culture 

 

Lab-on-a-Chip            Touchscreens      Underwater Communication

 

Main References


 Smart Prothesis

figure 5 Devices Armando

Position of the transducer in the different planes of the body figure. The anterior–posterior (AP) plane was defined by the Saggital plane. The medial–lateral (ML) plane was defined by the Frontal plane perpendicular to the AP plane.


figure 6 a Devices Armando  figure 6 b Devices Armando

(a)                                                                                         (b)

a) Transducer used in the Human study, b) the subject, 68 years old, transfemoral amputee in the right side, walked for 5 minutes in a crosswalk at a comfortable speed (0.33m/s);


 Protese1 Devices Vitor C

Picture of the hip-prosthesis with the implemented sensors in the stress-strain experimental setup: Piezoresistive measurement for the PeDot PR sensors performed with a maximum force of 4000 N for 1000 cycles.


 Protes2 Devices Vitor C

Smart hip prosthesis concept. The sensors are applied to the surface of the prosthesis and the battery and the reading and communication system is placed in a cavity of the inside of the prosthesis.


 

Bioreactors for Cell Culture

Biorreactor1 Vitor Correia

Bioreactor for the production of electromechanical-stimulation of cells. With these devices it is intended to simulate the real conditions that the cells are subjected in their native environment, promoting their differentiation.


Biorreactor2 Vitor Correia

Bioreactor for the production of electromechanical-stimulation of cells. With these devices it is intended to simulate the real conditions that the cells are subjected in their native environment, promoting their differentiation.


 

Lab-on-a-Chip

 

 

Microfluidic Devices vanessadesenho do sistema em camada 3 B

Polymer-based acoustic streaming system for microfluidic applications. Left: Photograph of a microfluidic system with a transparent P(VDF TrFE)-based piezoelectric transducer with patterned AZO electrodes placed underneath the PDMS structure (for the mixture of fluids based on the acoustic streaming phenomenon). The coaxial adapter is connected to the bottom and top AZO electrodes; Right: Schematic illustration of the various layers of the transparent P(VDF-TrFE)-based piezoelectric transducer. 

 

Uric acid    Nitrite

 

 Efficiency of the polymer-based acoustic streaming studied by means of two diagnostic kits: left: uric acid; right: nitrite.


 

Sem Título-1 sim

Continuous cleaning and separation of magnetic nanoparticle (from the inicial synthesis solution) in microfluidic systems: left: schematic representation; right: Microfluidic simulation for sizing the microfluidic system and flow in order to ensure a clean solution in the lower fluid output where the magnetic nanoparticles (in this case iron-oxide nanoparticle synthesis) are collected.

 

Resultados cleaning

 Gas chromatography characterization which prove the efficiency of the designed microfluidic system for the cleaning of magnetic nanoparticles.


 

 

Imagem lab-on-a-chip

Capture, transport, isolation and detection of histidine rich proteins on porous magnetic silica spheres.

 

Imagem lab-on-a-chip2

Representative TEM images and VSM results of magnetic silica spheres.

 


 

Touchscreens

 

figure 4 Devices Marcos

Drawing of a touchscreen based on the acoustic pulse recognition.
In figure it is showed a touchscreen based on acoustic pulse recognition. It uses piezoelectric transducers fabricated from the piezoelectric polymer poly(vinylidene fluoride), PVDF, in its beta phase. The transducers are located at the edges of the panel in order to receive the acoustic pulses generated by the touches. Each transducer is connected to a readout electronic circuit composed by a differential charge amplifier and a comparator, whose output signal is attached to a microcontroller. The microcontroller uses an algorithm to determine the location of the touch, based on the time differences of the transducer signals. The touchscreen itself is made of ordinary glass, providing good durability and optical transparency.


 

Underwater Communication

 

figure 3 Devices Marcos

In the Figure, a network architecture that can respond to the actual needs of wireless underwater networks to support high-speed and real time communications is presented.
The Figure shows that the very long distance communications can be forwarded to air links. In this way, the propagation time is reduced. In the surface there are routers to convert the acoustic or optical links in RF-EM airborne links. Underwater, mobile agents communicate through high speed acoustic at a range of hundreds of meters. The static agents or routers can communicate between each other through high speed acoustic or optical links. To larger depths, multiple routers can be placed at different vertical levels that can communicate with each other via high speed acoustic or optical links. On the ocean floor, static agents or routers, connected to each other through electrical or optical wires can be placed, to support a high data rate network. The routers near the coast can be connected to land stations using wires too.


 

Main References

  • V. Correia, C. Caparros, C. Casellas, L. Francesch, J. G. Rocha, and S. Lanceros-Mendez. "Development of inkjet printed strain sensors".Smart Materials and Structures, Struct. 22 105028, DOI: 10.1088/0964-1726/22/10/105028, 2013.
  • V. Correia, V. Sencadas, M. S. Martins, C. Ribeiro, P. Alpuim, J. G. Rocha, I. Morales, C. Atienza, and S. Lanceros-Mendez."Piezoresistive sensors for force mapping of hip-prostheses".Sensors and Actuators, A: Physical, vol. 195, pp. 133–138, 2013. DOI: 10.1016/j.sna.2013.03.013
  • C. Ribeiro, S. Moreira, V. Correia, V. Sencadas, J. G. Rocha, F. M. Gama, J. L. Gomez Ribelles, and S. Lanceros-Mendez. "Enhanced proliferation of pre-osteoblastic cells by dynamic piezoelectric stimulation,".RSC Advances., vol. 2, no. 30, pp. 11504–11509, 2012. DOI: 10.1039/C2RA21841K.
  • V.F.C ardoso, T. Knoll, T. Velten, L. Rebouta, P. M. Mendes, S. Lanceros-Méndez, G. Minas- Polymer based acoustic streaming for microfluidic applications. RSC Advances (Accepted).
  • V. F. Cardoso, S. O. Catarino, J. S. Nunes, L. Rebouta, J. G. Rocha, S. Lanceros-Méndez, G. Minas - Lab-on-a-chip with ß-PVDF based acoustic microagitation. IEEE Transactions on Biomedical Engineering. Vol. 57 (2010), pp. 1184-1190. Doi: 10.1109/TBME.2009.2035054. 
  • V. F. Cardoso, C. M. Costa, G. Minas,S. Lanceros-Mendez - Improving optical and electroactive response of poly(vinylidene fluoride-trifluoroethylene) spin coated films for sensor and actuator applications. IOP Science – Smart Materials and Structures. Vol. 21 (2012) 085020. Doi: 10.1088/0964-1726/21/8/085020. 
  • S. Reis, V. Correia, M. Martins, G. Barbosa, R. M. Sousa, S. Lanceros-Mendez and J. G. Rocha, "Touchscreen based on acoustic pulse recognition with piezoelectric polymer sensors", ISIE 2010. DOI:http://dx.doi.org/10.1109/ISIE.2010.5637672.